IgA antibodies to Streptococcus mutans in caries-resistant and -susceptible children.
نویسندگان
چکیده
Previous studies have shown a positive correlation between salivary IgA antibody levels to Streptococcus mutans and caries resistance in adults. In this study, enzyme-linked immunosorbent assay (ELISA) was used to compare IgA antibody levels with S. mutans in whole and parotid saliva from 20 caries-susceptible (CS; DMFS > 5) and 20 caries-resistant (CR; DMFS < or = 1) children (aged 7-11 years). Whole salivary S. mutans numbers were significantly greater (P < or = 0.05) in the CS group (mean of 31.2% of total oral streptococci) than in the CR group (mean of 1.6% of total oral streptococci). Whole saliva, but not parotid saliva, from CR children had significantly higher (P < or = 0.05) levels of IgA antibodies to S. mutans than saliva from CS children. These results suggest that salivary IgA antibodies to S. mutans may play a role in natural protection from dental caries in children and that the source of increased salivary IgA antibody in CR children may be either the minor, submandibular, or sublingual salivary glands.
منابع مشابه
Salivary immunoglobulin A and serum antibodies to Streptococcus mutans ribosomal preparations in dental caries-free and caries-susceptible human subjects.
Caries-free subjects or individuals with low caries susceptibility exhibited significantly higher (P less than 0.001) levels of naturally occurring salivary immunoglobulin A (IgA) and serum IgG, IgA, and IgM antibodies to a Streptococcus mutans ribosomal preparation than subjects with high caries susceptibility. Absorption of saliva and serum samples with S. mutans ribosomal preparations, but n...
متن کاملAntibodies to indigenous and laboratory strains of Streptococcus mutans in saliva from children with dental caries and from caries-free children.
Whole, unstimulated saliva and dental plaque were collected from 63 children ages 6-13 years, 29 with dental caries and 34 without. If a child was infected with Streptococcus mutans, it was isolated from dental plaque and characterized. Saliva was tested for IgM, IgG, and IgA that would bind indigenous S. mutans, if present, and for antibodies that would bind 6 laboratory strains of S. mutans, ...
متن کاملThe Comparison of Proteins Elaborated by Streptococcus mutans Strains Isolated from Caries Free and Susceptible Subjects
متن کامل
The Frequency of Streptococcus Mutans and Lactobacillus spp.in 3-5-year- old Children with and without Dental Caries
Abstract Background and Objective: The high occurrence of early childhood caries (ECC) is one of the most common problems in children dentistry. Streptococcus mutans and lactobacilli.spp are closely associated with the development of early childhood caries (ECC). Therefore, the aim of this study was to investigate the frequency of streptococcus mutans and lactobacilli.spp in 3-5 –year- old ch...
متن کاملEffect of restorative treatment on mutans streptococci and IgA antibodies.
PURPOSE Streptococcus mutans has been implicated as the major causative agent of dental caries. Although restorative treatment for caries is thought to temporarily eliminate the carious challenge, there are few reports of alterations in salivary mutans streptococci (MS) numbers and no reports of changes in salivary IgA antibody to S. mutans following restorative treatment. METHODS This study ...
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عنوان ژورنال:
- Pediatric dentistry
دوره 16 4 شماره
صفحات -
تاریخ انتشار 1994